Joaquín Castilla Selected Research

Prions

12/2021	Biosemiotics comprehension of PrP code and prion disease.
1/2021	Prion-Associated Neurodegeneration Causes Both Endoplasmic Reticulum Stress and Proteasome Impairment in a Murine Model of Spontaneous Disease.
1/2020	Detection of Pathognomonic Biomarker PrPSc and the Contribution of Cell Free-Amplification Techniques to the Diagnosis of Prion Diseases.
1/2020	Dogs are resistant to prion infection, due to the presence of aspartic or glutamic acid at position 163 of their prion protein.
10/2019	Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies.
9/2019	A Single Amino Acid Substitution, Found in Mammals with Low Susceptibility to Prion Diseases, Delays Propagation of Two Prion Strains in Highly Susceptible Transgenic Mouse Models.
8/2019	Insights into the Bidirectional Properties of the Sheep-Deer Prion Transmission Barrier.
7/2018	An Amino Acid Substitution Found in Animals with Low Susceptibility to Prion Diseases Confers a Protective Dominant-Negative Effect in Prion-Infected Transgenic Mice.
1/2018	Behind the potential evolution towards prion resistant species.
12/2017	In Vitro Approach To Identify Key Amino Acids in Low Susceptibility of Rabbit Prion Protein to Misfolding.

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Joaquín Castilla Research Topics

Disease

41	Prion Diseases (Transmissible Spongiform Encephalopathies) 12/2021 - 01/2004
17	Infections 06/2021 - 05/2004
14	Scrapie 12/2021 - 03/2005
13	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 01/2005
10	Bovine Spongiform Encephalopathy (Mad Cow Disease) 12/2017 - 05/2004
7	Chronic Wasting Disease 08/2019 - 08/2008
4	Alzheimer Disease (Alzheimer's Disease) 01/2017 - 01/2013
4	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 04/2015 - 06/2009
3	Parkinson Disease (Parkinson's Disease) 01/2018 - 09/2015
3	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2017 - 01/2013
2	Brain Diseases (Brain Disorder) 12/2021 - 01/2015
2	Pathologic Processes 12/2021 - 01/2013
2	Erythropoietic Porphyria (Congenital Erythropoietic Porphyria) 05/2021 - 01/2018
2	Communicable Diseases (Infectious Diseases) 09/2015 - 01/2013
1	Gliosis 01/2021
1	Autoimmune Diseases (Autoimmune Disease) 10/2020
1	Amyloidosis 01/2017
1	Amyloid Plaque 09/2015
1	Fatal Familial Insomnia 04/2015
1	Inborn Genetic Diseases (Disease, Hereditary) 12/2013
1	Proteostasis Deficiencies 03/2006
1	Neuroblastoma 03/2005
1	Asymptomatic Infections 05/2004

Drug/Important Bio-Agent (IBA)

46	PrionsIBA 12/2021 - 05/2004
38	Prion ProteinsIBA 12/2021 - 05/2004
16	Proteins (Proteins, Gene)FDA Link 12/2021 - 01/2005
9	Protein Isoforms (Isoforms)IBA 12/2021 - 06/2009
6	Amino Acids FDA Link 01/2020 - 12/2013
5	Amyloid (Amyloid Fibrils)IBA 01/2018 - 07/2005
2	Biomarkers (Surrogate Marker)IBA 06/2021 - 01/2020
2	Endopeptidase K (Proteinase K)IBA 06/2021 - 01/2004
2	Uroporphyrinogen III Synthetase (Uroporphyrinogen-III Synthase)IBA 05/2021 - 01/2018
2	Ciclopirox (Loprox)FDA LinkGeneric 05/2021 - 01/2018
2	EnzymesIBA 05/2021 - 01/2018
2	Heme (Haem)IBA 05/2021 - 01/2018
2	Codon (Codons)IBA 10/2020 - 03/2013
2	Biological ProductsIBA 08/2019 - 01/2014
2	Methionine (L-Methionine)FDA Link 10/2017 - 03/2013
2	Isoleucine (L-Isoleucine)FDA Link 10/2017 - 03/2013
1	alpha-SynucleinIBA 12/2021
1	tau Proteins (tau Protein)IBA 12/2021
1	MicroRNAs (MicroRNA)IBA 06/2021
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2021
1	ferric oxide (iron oxide)IBA 01/2021
1	Immunoglobulin G (IgG)IBA 10/2020
1	AutoantibodiesIBA 10/2020
1	Complement System Proteins (Complement)IBA 01/2020
1	SolutionsIBA 01/2020
1	Glutamic Acid (Glutamate)FDA Link 01/2020
1	Pharmaceutical PreparationsIBA 01/2018
1	AntigensIBA 05/2017
1	Membrane Glycoproteins (Membrane Glycoprotein)IBA 01/2017
1	meso- tetrakis(1- methyl- 4- pyridiniumyl)porphyrinIBA 03/2016
1	Peptide Hydrolases (Proteases)FDA Link 01/2016
1	Protein AggregatesIBA 09/2015
1	AA amyloidosisIBA 09/2015
1	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2007
1	LipidsIBA 06/2007
1	coenzyme Q10 (CoQ10)IBA 06/2007
1	UbiquinoneIBA 06/2007
1	AntioxidantsIBA 06/2007
1	Small Interfering RNA (siRNA)IBA 03/2005
1	PrPSc ProteinsIBA 05/2004

Therapy/Procedure

2	Therapeutics 03/2016 - 01/2013
1	Cell- and Tissue-Based Therapy (Cell Therapy) 12/2015